PokerTracker

I am looking to have a 3 bet % stat against my preflop 2 bets. Basically how often is someone 3 betting my 2 bets rather than overall?

I understand this stat would require a huge sample to be of any relevance but I do have such a sample on quite a few players.

That would require a custom statistic - see this guide for the basics on custom statistics creation and this guide for a deeper walkthrough. There is also a thread here on the topic of 'vs Hero' custom statistics.